Systemic Causes of Haematological Changes #2

Acute Phase Reactants
- general indication of inflammatory resp
eg
Fibrinogen
Complement
CRP
Haptoglobin
Ferritin
Serum amyloid protein

Ix
Presence & extent of inflamation + resp to Tx


ESR
Red cell sedimentation through plasma in 1hr
 - cheap
 - dependant on plasma concentration of large proteins - immglob/fibrinogen
 - raised - chronic infection/myeloma/dissem malig/AI
 - aff by red cell concentration - low in polycythaemia & high in An

Normal range
Men < 5mm/hr
Females < 15mm/hr
Increases with age


Plasma Viscosity
n(1.5-1.7 mPa/s)
15min test
Slight increase with age
Unaffected by red cell changes


CRP
Rapid increase to tiss inj (4-6hrs)
Highly sens
Unaff by RC Changes

?poss - paraproteinaemias