Decrease in plts prolongs bleeding
(>50 is still okay)
Important to know in case of invasive procedures eg LP
Important to know in case of invasive procedures eg LP
Sy
Purpura/mucosal bleeding
Purpura/mucosal bleeding
Tx
Plts < 10 = daily transfusion of plt concentrate obtained w/i last 72 hours
Plts < 10 = daily transfusion of plt concentrate obtained w/i last 72 hours
Relatives/HLA-matched donors - plt-pheresed on cell separator
Short life-span, so in 24h = x sustained increase in no.
Short life-span, so in 24h = x sustained increase in no.
Plt count unreliable mesr of effectiveness
Effective transfusion?
1) Cessation of bleeding
2) Incrs in plt count >20 over baseline, after 1 hr-post transfusion
Effective transfusion?
1) Cessation of bleeding
2) Incrs in plt count >20 over baseline, after 1 hr-post transfusion
Problems
HLA aBs in pt (if not matched)
Continued plt consumption at bleeding sites
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