Marrow Failure - Anaemia

Symptoms
Tiredness
Dyspnoea
Angina

Ex
Pale mucous membranes eg eyes

Tx
Transfusion = Packed cells/plasma reduced red cells (NB vol overload)
Adult = 1 unit of blood : 1g/dl in Hb
Aim in-patient = Hb 9-10g/dl
Severe An (Hcrit<.30) = Prolonged BT & can worsen Tbcytopenia

Transfusion reactions
Prev transfusions = antibodies against blood components
eg
- HLA Ag (found on WC & plts)
therefore can = NHFTRs (non-haemolytic febrile transfusion reactions) - from dead WC&Plts in red cells units

Immunocompromised
Require CMV-ve (found dormant in lymphocytes) blood
40% UK donors CMV-ve
Patient CMV aB+ve status useful to establish

Cx
Heart failure