Tropical Sprue
Coeliac-like disease
Tropics
Aetiology
?Spec cause
Poss bacterial overgrowth (eg Ecolab/Haemophilic)
Small intestine (entire)
Presentation/CFx
*folate/B12 deficiency - pernicious anaemia
Ix
Micro
Variable
Tx
B-Sp ABs
Cx
x a/w/ T Cell lymphoma
Whipple's Disease
Rare
Systemic
*Intestine/CNS/Joints
Epidemiology
*White
M:F=10:1
*30-40yrs
Aetiology
G+ve Actinomycete - Tropheryma whippelii
Ix
Biopsy/Micro
PAS +ve macrophages within LProp =
SmI distension
E- Micro
Macrophages contain rod shaped bacilli
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