Tuesday, 20 April 2010

Interstitial Lung Disease - Goodpasture's Syndrome & Wegener's Granulomatosis

Interstitial Lung Disease


Goodpasture's Syndrome
Autoantibodies to alveolar basement membrane
= pulmonary Hg & fibrosis

Autoantibodies to glomerular basement membrane
= proliferative, crescentic glomerulonephritis

Ix
serum anti-BM (basement membrane) antibodies


Wegener's Granulomatosis
Systemic vasculitis
Necrotising, granulomatous inflammation in upper and lower respiratory tract
= pulmonary Hg & fibrosis

*assoc/ w/ proliferative, crescentic glomerulonephritis

Ix
serum C-ANCA (anti-neutrophil cytoplasmic antibody)

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