GIT Viral Infections

Virus types
RotaV (2/RNA)
AdenoV (2/DNA)
AstroV
SRSVs/CaliciV

With Non-GI Symptoms
HepA
EnteroVs (polioV)

Characteristics
ALL unsegmented 1 stranded/RNA
Except...
RotaV - segmented 2-stranded/RNA
AdenoV 2-stranded/DNA

Signs and symptoms
D/N/Vg
Abdo cramps
Fever
D&V = severe dehydration & hypoNa

Epidemiology
*infant mortality in developing world
*children (also more severe)
a/w/ overcrowding/poor sanitation/poverty

Transmission
* F/O
Contaminated food/H20
Vomitus - SRSV-a/ GE (caliciV)

Dx
Stool samples
E-Micro/ELISA/Latex agglutination
*Useful in outbreaks
PCR
Research only
Tissue Culture
Not helpful (Viruses fastidious)

Tx
Symptomatic
Rehydration
Replace Na loss

Prevention
Hygiene
Food preparation
Clean H20
Good sewage disposal
Hospitals - hand washing, source isolation
Vaccines - polio, hep A