CYP450 Inducers and Inhibitors

Argh - the CYP450 inducers and inhibitors are another thing that we HAVE to know that I have spent 3 years avoiding, like following after a fat man for an airplane toilet...

....hmmm. I appear to get more offensive when irritated and sleepy.

CYP 450 - in case pharmacology wasn't complicated enough.


INHIBITORS - act acutely

•Valproate
•Ketoconazole
•Ciprofloxacin
•Cimetidine
•Erythromycin
•Grapefruit juice
•Isoniazid

Venerated Key Pros I Met STOP Eating Grapefruit, Son

(Valproate, Ketoconazole, Ciprofloxacin, Cimetidine, Erythromycin, Grapefruit, Isoniazid)


INDUCERS - act slowly

•Phenytoin
•Alcohol
•Tobacco
•Rifampicin
•Griseofulvin
•Carbamazepine

Penny QUICKLY Drinks and Smokes but Refuses Greasy Carbs.

(Phenytoin, Alcohol, Tobacco, Rifampicin, Griseofulvin, Carbemazepine)

CYP 450 drugs with Narrow Therapeutic Window (DUM DUM DA!!!!)

Phenytoin
Cyclosporin
Estradiol
Theophylline
Warfarin

Penny Cycled Straight by The Wharf
(Phenytoin, Cyclosporin, Estradiol, Theophylline, Warfarin)

Narrow Therapeutic Window Drugs + CYP 450 inhib/inducer = Pot Drug AE!!!

These took forever to come with... yes I am that unimaginative.

xx