CYP450 Inducers and Inhibitors

Argh - the CYP450 inducers and inhibitors are another thing that we HAVE to know that I have spent 3 years avoiding, like following after a fat man for an airplane toilet...

....hmmm. I appear to get more offensive when irritated and sleepy.

CYP 450 - in case pharmacology wasn't complicated enough.


INHIBITORS - act acutely

•Valproate
•Ketoconazole
•Ciprofloxacin
•Cimetidine
•Erythromycin
•Grapefruit juice
•Isoniazid

Venerated Key Pros I Met STOP Eating Grapefruit, Son

(Valproate, Ketoconazole, Ciprofloxacin, Cimetidine, Erythromycin, Grapefruit, Isoniazid)


INDUCERS - act slowly

•Phenytoin
•Alcohol
•Tobacco
•Rifampicin
•Griseofulvin
•Carbamazepine

Penny QUICKLY Drinks and Smokes but Refuses Greasy Carbs.

(Phenytoin, Alcohol, Tobacco, Rifampicin, Griseofulvin, Carbemazepine)

CYP 450 drugs with Narrow Therapeutic Window (DUM DUM DA!!!!)

Phenytoin
Cyclosporin
Estradiol
Theophylline
Warfarin

Penny Cycled Straight by The Wharf
(Phenytoin, Cyclosporin, Estradiol, Theophylline, Warfarin)

Narrow Therapeutic Window Drugs + CYP 450 inhib/inducer = Pot Drug AE!!!

These took forever to come with... yes I am that unimaginative.

xx

Snippets #1 - NYHA Classification of Breathlessness

Okay - so we're supposed to know this. Random but essential.

I - only vigorous exercise.
II - only moderate exercise.
III - mild at rest
IV - significant at rest/often bed-bound

The Big-Ass List of Things To Do

Okay this is the theory - if you can explain something, that means you can understand it.

Excluding management consultants, of course.

So here is my blog in preparation for medical finals, with regular posts showing off how well I understand everything medical ever. Sure. And a summary of the topics I need to cover...

List of Things To Cover

Skills:
Clinical Skills
Data Interpretation
Specialist Examinations
Safe Prescribing
History Taking
Pharmacology
Practical Skills
Ethics and Law
Forms/Certificates/Discharge Summaries
Managing acute patients
Managing the sick patient
Differentials
Communication Skills
Key Scenarios
Case of the Month

Subjects:
Endocrinology
Nephrology/Kidney
Haematology
Infectious Diseases
Cardiovascular
Neurology
Care of the Elderly
ENT
Orthopaedics
Rheumatology
General Surgery
Respiratory
Gastroenterology
General Practice
Oncology
Palliative Medicine
Opthalmology

Understanding
- Epidemiology
- Aetiology/Pathogenesis
- Presentation
- Ix/Dx
- Mx
- Public Health and Prevention

Oh, pants.